Piroxicam (NSAID) a poorly soluble drug is widely used in the painful indications like rheumatoid and osteoarthritis. The dissolution rate of piroxicam can be increased by formulating it into orodispersible tablets, as these dosage forms disintegrate very rapidly into fine suspension of drug particles resulting in higher surface area of drug. Though, several disintegrants are available, there is continuous need to develop newer disintegrants to have more disintegration and dissolution efficiency. The present research work involves preparation, characterization and evaluation of starch maleate as a super disintegrant. The prepared starch maleate was found to be free flowing and amorphous. FT-IR studies revealed the formation of ester, when starch and maleic anhydride acid were reacted with DMSO in the presence of acetone. The disintegrating nature of starch maleate (5%) was found to be very less, when compared to sodium starch glycolate. In-vitro release of piroxicam was also found to be greater i.e., 99.89% in 10 minutes in the formulations employing starch maleate as disintegrant. Therefore, starch maleate a new modified starch was found to be a promising disintegrant in the formulation of orodispersible tablets of poorly soluble drugs.
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